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Biomechanical alterations of the ECM, including increased ECM rigidity or forces of varying strengths and dynamic characteristics, modulate form and the functions of cells with an inevitable impact on the cellular behavior and therefore drive distinct fibrotic signaling pathways (Orr et al., 2006

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Treatment with CAPE primarily boosted the genera Helicobacter , Bilophila , Enterococcus , and Bacteroides (190)

But the crucial point here is that consistency (NOT avoidance) is the key

In SSc, fibroblasts differentiate into myofibroblasts, a process characterized by excess production of SMA

Vitamin B12 injections offer a range of health benefits and can be particularly advantageous for individuals with B12 deficiency, pernicious anemia, or conditions that impair B12 absorption, such as gastrointestinal disorders (e.g., Crohns disease or celiac disease)